I don't ask my guests to strip the bed or clean for a couple of reasons:
1) It only takes a couple minutes to strip the beds & gives me a chance to look for damage, bed bugs, or other issues. (if there ever IS a bedbug issue, it's not made worse by transporting infested linens)
2) Nobody likes cleaning at the end of their vacation & it can inconvenience them (if they're supposed to do a full load of wash/dry, but need to leave the house by 8am, they have to get up at 6:30 to start laundry? Yuck.)
3) I'm better able to manage laundry than they are: They didn't notice a stain I could have treated & now it's set. They started laundry at an inconvenient time, and it sat wet for several hours and now smells musty. I'm going to have to re-wash it before drying anyway.
You can ask them to strip the beds if you'd like, but asking them to do laundry (IMO) is too much and is likely to cause other problems.